Endocrine Abstracts

Objective: The thyroid fine needle aspiration biopsy (FNAB) may bring inconclusive cytological results of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) or follicular neoplasm/suspicious for follicular neoplasm (FN/SFN). The objective of the study was to describe the genetic landscape of indeterminate thyroid nodules to better understand this phenomenon and identify genetic markers potentially differentiating benign and malignant ...

Introduction: The aim of the present study was to compare follicular thyroid adenoma (FTA) and follicular thyroid carcinoma (FTC) using the wide oncological molecular panel and identify differences in mutational status which may aid in the preoperative differentiation between these two related thyroidal pathologies, as well as in an understanding their pathways of origin.Material and methods: We analyzed formalin-fixed paraffin-embedded (FFPE) samples ac...

Introduction: Pre- and postsurgical differentiation between follicular thyroid adenoma (FTA) and follicular thyroid cancer (FTC) represents a significant diagnostic challenge. Typical markers of malignancy may appear as specific genetic alterations. Next-generation sequencing (NGS) studies bring information about single point mutations, however better insight into follicular thyroid lesions genetic landscape, encompassing bigger rearrangements, is needed.<p class="abstext"...